Type 1 diabetes low blood pressure, Low Calorie Diet and Diabetes
Karolinska University Hospital Rövid összefoglaló The primary hypothesis is to investigate whether a low calorie diet for 7 weeks followed by continuous lifestyle advice is an effective option to achieve an improvement in glucose control as measured by HbA1c after 52 and weeks as compared to baseline values in obese type 2 diabetes patients on either tablet or insulin treatment.
Current medical wisdom advises that anyone suffering from diabetes or prediabetes should eat a low-carbohydrate, high-fat diet. While it may improve short-term blood glucose control, such a diet also increases the long-term risk for chronic diseases like cancer, high blood pressure, high cholesterol, chronic kidney disease, and fatty liver disease. The revolutionary solution is to eat a low-fat plant-based whole-food diet, the most powerful way to reverse insulin resistance in all types of diabetes: type 1, type 1.
The secondary hypothesis is to investigate whether the weight reduction therapy also has significant impact on various anthropometric, clinical and metabolic parameters associated with obesity. Részletes leírás This is a prospective study on the impact of low calorie diet followed by a weight maintenance program on 12 and 24 month glucose control in a cohort of patients with obesity and diabetes mellitus.
The study will consist of 3 phases: 1. Screening period up to 12 weeks.
Low calorie diet weeks At entry of the LCD-period, all medication for diabetes mellitus, with the exception of metformin and insulin, will be removed. During the LCD-period, insulin treatment will gradually be reduced and, if possible, withdrawn.
The correlation between cardiovascular disease and psychosocial factors including concomitant mental disorders as well as personality traits or the effect of social environment has been established in numerous studies aimed at investigating pathogenesis or various clinical endpoints. The Guidelines of the European Society of Cardiology include the assessment and the management of psychosocial problems with behavioral medicine interventions as a I. A level recommendation.
Patients will perform daily self-monitoring of fasting and post-prandial plasma glucose. At each visit, which will take place once a week, the patients will see a physician, a nurse and a dietician.
The patients will be given specific advice to increase their physical activity. Patients will remain on medication for dyslipidemia.
Weight-maintenance program weeks Follow up visits at months 15, 18, 21 and Átfogó állapot.