Diabetes, obesity and metabolism
PubMed: Szakterületek: The aim was to determine the effects of dulaglutide, a synthetic once-weekly, injectable human glucagon-like peptide 1 analogue that lowers blood glucose, body weight, appetite and blood pressure, on cardiovascular outcomes.
People with type 2 diabetes, aged 50years, with glycated haemoglobin HbA1c 9.
The primary cardiovascular outcome is the first occurrence of the composite of cardiovascular death or non-fatal myocardial infarction or non-fatal stroke. Secondary outcomes include each component of the primary composite cardiovascular outcome, a composite clinical microvascular outcome comprising retinal or renal disease, hospitalization for unstable angina, heart failure requiring hospitalization or an urgent heart failure visit, and all-cause mortality.
Follow-up will continue until the accrual of confirmed primary outcomes. The mean duration of diabetes was 10years, mean baseline HbA1c was 7.
The REWIND trial's international scope, high proportion of women, high proportion of people without prior cardiovascular disease and inclusion of participants obesity and metabolism mean baseline HbA1c was 7.