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Ace inhibitors diabetic nephropathy mechanism

Az előadások a következő témára: "Az idült vesebetegség progressziójának"— Előadás másolata: 1 Az idült vesebetegség progressziójának csökkentése, szövődményeinek kezelése Dr.

Belgyógyászati KlinikaBudapest, Korányi S. A társaságok tagjai számára ingyenes. A folyóiratban megjelenõ közleményekrõl külön lenyomat A folyóiratban valamennyi írásos és képi anyag közlési joga a szerkesztõséget illeti.

Angiotensin Converting Enzyme (ACE) Inhibitors

A megjelent anyag, illetve annak egy részének bármilyen formában történõ másolásához, ismételt megjelentetéséhez a szerkesztõség hozzájárulása szükséges. On the one hand, renal dysfunction and particularly renal disease can cause an increase in blood pressure, while on the other hand, high blood pressure accelerates loss of function of the diseased kidney. Transplantation studies, both in experimental animals and humans, documented that blood pressure goes with the kidney : a normotensive recipient of a kidney genetically programmed for hypertension will become hypertensive, while conversely hypertensive patients with renal failure receiving the kidney of a normotensive donor may become normotensive.

Family studies showed higher blood pressure values and more frequent hypertension in first degree relatives of patients with primary glomerulonephritis or diabetic nephropathy, suggesting that genes coding for hypertension increase also the risk of renal disease.

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The mechanisms through which blood pressure increases in renal disease comprise: salt and water retention, inappropriate activity of the renin angiotensin system RAS and of the sympathetic nerve system as well as impaired endothelial cell-mediated vasodilatation. There is ample evidence, both in primary renal disease and in nephropathy of type 1 or type 2 diabetes, that pharmacological blockade of the RAS by angiotensin converting enzyme inhibitors ACEI or angiotensin II type 1 receptor blockers ATRB has blood pressure-independent renoprotective effects, and may reduce proteinuria.

Major, SG: Blood pressure in diabetes mellitus: a statistical study. Arch Int Med ,

Since, according to recent concepts, proteinuria is a nephrotoxin, apart from blood pressure, proteinuria is a further and partially blood pressure independent indication for antihypertensive treatment using ACEI or ATRB for patients with diabetic nephropathy or primary renal diseases. Brenner ace inhibitors diabetic nephropathy mechanism proposed the hypothesis, that deviations of the kidney structure are found in patients with so called essential hypertension i.

This hypothesis is supported by a number of experimental and clinical observations.

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Stereologic investigation of the kidney revealed significant glomerular enlargement 2. Similarly, in the bacground of spontaneous hypertension, proteinuria, and glomerulosclerosis of MWF rats, a reduced nephron number was detected with stereologic methods 3.

Introduction

The number of glomeruli and glomerular volume were investigated stereologically with a modified Gundersen fractionator method. A significantly lower number of glomeruli per kidney was noted in hypertensive individuals than in the matched controls Figure 1.

At the same time, the glomerular volume was significantly greater in hypertensive individuals than in matched controls Figure 1. Such increase in glomerular volume may constitute a compensatory mechanism.

Of course it was important to exclude one artefact, i.

lábápolás népi jogorvoslat a diabetes

In this study there was no histological evidence of glomerular loss hypertensive nephropathy. The findings of this postmortal human study fits nicely with a series of animal experiments which have shown that hypertension and normotension can be transferred from a donor to a recipient by transplanting a kidney, i.

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The most elegant studies on this topics were reported by Rettig et al 6. He showed that, transplantation of a kidney from a genetically hypertensionprone donor rat, even when it had been kept normotensive from weaning by antihypertensive medication, caused a progressive increase of blood pressure in a recipient animal which was immunologically manipulated to prevent rejection.

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This finding is extremely interesting: a kidney genetically programmed to develop high blood pressure forces an organism programmed for normotension to develop hypertension, although the recipient s central nervous system, volume control systems, sympathetic nervous system, heart function etc are all geared for normotension. In contrast, and quantitatively less impressive, transplantation of a kidney from a donor genetically programmed for normotension lowered blood pressure in the recipient 7.

Although animal experiments are very nice, most reader of this paper deal with hypertensive patients and not hypertensive rats. Is the above experimental observation also true for humans?

Az előadások a következő témára: "Az idült vesebetegség progressziójának"— Előadás másolata:

Of course, no controlled studies are available where kidneys from patients with essential hypertension were transplanted to normotensive recipients or conversely. However uncontrolled data strongly suggest that recipients of kidneys from donors with essential hypertension develop hypertension more frequently than recipients of kidneys from normotensive donors 8, 9.

It has also been shown that kidney graft recipients required more antihypertensive medication if the grafts had been obtained from genetically hypertension-prone donors 8.

In particular, recipients of kidneys from ace inhibitors diabetic nephropathy mechanism dying from cerebral ace inhibitors diabetic nephropathy mechanism, presumably caused by hypertension, had a higher risk to develop hypertension 9.

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Because of numerous scores ±0. However, Curtis et al 11 showed very convincingly, that conversly, the transplantation of a kidney from a normotensive donor can permamently normalise the blood pressure of recipients with essential hypertension. He studied 6 black patients with essential hypertension of unknown origin who became dialysis dependent as a result of hypertensive nephrosclerosis without any histologic signs of primary kidney disease.

After these patients had received a kidney from a normotensive donor, all of them became normotensive and this persisted during a 4. There was evidence of reversal of hypertensive damage to the heart and retinal vessels, and of completely normal blood pressure responses to salt deprivation and salt loading.

Tartalomjegyzék

Which factors, genetic or environmental, could be potentially responsible for the hypertensinogenic effects of the kidney and, according to Brenner s hypothesis for so called nephron underdosing? Since the pioneering experiment of Weitz in the ies of the last century we know that genetic factors play a key role in essential hypertension We must, therefore, suppose that the number of functional nephrons is genetically determined.

az 1-es típusú diabetes mellitus kezelésének módja

This hypothesis is also supported by the race dependent differences in glomerular count in humans However, there are also many animal experiments and human studies which suggest that during the fetal period environmental factors may also influence renal 0. Langley et al 14 have shown that dietary protein restriction of pregnant rats caused high blood pressure in the offspring. In humans Merlet-Benichou et al 15 showed that newborns with lower birth weight as an indirect sign of fetal malnutrition had a lower nephron number than newborns with normal birth weight.

The role of the kidney in the pathogenesis of essential hypertension is probably not only due to potential structural alterations, such as lower nephron number, but also due to changes in kidney function.

Download 1MB Abstract A cigarettafüst korai, idő- és dózisfüggő károsodást okoz az endotéliumban. Több ponton is akadályozza a nitrogén monoxid NO termelését: egyrészt az endoteliális NO szintáz eNOS aktivitását befolyásoló foszforilációt gátló irányba tolja, másfelől megakadályozza az eNOS dimerizációját, mely az enzim aktív állapotát jelentené.

According to this concept, because the gain of the blood-pressure-natriuresis relationship overrides all other regulatory systems, the ultimate determinant of blood pressure must always be the renal handling of sodium. It is interesting that renal function, as reflected by the blood pressure-natriuresis relationship, can be disturbed as a consequence of extrarenal causes.

Lombardi et al 17 performed a very interesting experiment.

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However when normotensive rats had temporarily been rendered hypertensive by infusing angiotensin II and after they had subsequently become normotensive when angiotensin II infusion had been stopped, they had permanently become sodium sensitive. The kidney remembered so to speak the injury induced by angiotensin II. Kezelés news cukorbeteg these animals were later exposed to a high sodium intake their blood pressure increased and they again developed hypertension.

Lozartán – Wikipédia

The shift of the blood pressure-natriuresisrelationship under hormonal influences such as mineralo and glucocorticoid excess 18testosteron 19 and estrogen 20 etc is well known. However it is also interesting that for example dietary factors such as high intake of unsaturated fatty acid 21or high potassium intake 22, 23 can shift this relationship.

These experimental findings prompted the DASH study, designed to investigate the influence of such dietary factors on blood pressure in humans